El-Sayed, M., EL-Dashlouty, M., Merika, E. (2023). RESTORING ANTIOXIDANT LEVELS OF NICOTINE-INJECTED RATS USING SUGGESTED DIETARY FORMULAS. Menoufia Journal of Food and Dairy Sciences, 8(10), 97-117. doi: 10.21608/mjfds.2023.245464.1006
M.M El-Sayed; M. S EL-Dashlouty; Eslam Al-Amir Merika. "RESTORING ANTIOXIDANT LEVELS OF NICOTINE-INJECTED RATS USING SUGGESTED DIETARY FORMULAS". Menoufia Journal of Food and Dairy Sciences, 8, 10, 2023, 97-117. doi: 10.21608/mjfds.2023.245464.1006
El-Sayed, M., EL-Dashlouty, M., Merika, E. (2023). 'RESTORING ANTIOXIDANT LEVELS OF NICOTINE-INJECTED RATS USING SUGGESTED DIETARY FORMULAS', Menoufia Journal of Food and Dairy Sciences, 8(10), pp. 97-117. doi: 10.21608/mjfds.2023.245464.1006
El-Sayed, M., EL-Dashlouty, M., Merika, E. RESTORING ANTIOXIDANT LEVELS OF NICOTINE-INJECTED RATS USING SUGGESTED DIETARY FORMULAS. Menoufia Journal of Food and Dairy Sciences, 2023; 8(10): 97-117. doi: 10.21608/mjfds.2023.245464.1006
RESTORING ANTIOXIDANT LEVELS OF NICOTINE-INJECTED RATS USING SUGGESTED DIETARY FORMULAS
1Dept. of Nutrition and Food Science, Faculty of Home Economics, Menoufia University,
2Dept. of Nutrition and Food Science, Faculty of Home Economics, Menoufia University,
Shibin El Kom, Egypt
Abstract
: This study was conducted to investigate the effect of tested dietary formulas on restoring antioxidant levels in rats that were injected with nicotine. Fifty male albino adult rats (150±10 g) were used. Rats were fed on basal diet for 7 consecutive days and then divided into two main groups. The first main group (5 rats) fed on a basal diet as a control negative group (-ve) (group 1), while the second main group (45 rats) was injected with nicotine subcutaneously for 7 days. The second main group divided into nine groups (5 rats each). Group (2) (control positive group +ve) fed on basal diet also and eight other rats groups fed on supplemented diet with (prickly pear seeds + sunflower seeds + celery seeds) (1:1:1) (5 & 10%), (prickly pear germinated seeds + sunflower germinated seeds + celery germinated seeds) (1:1:1) (5 & 10%), (cape gooseberry + carob+ doum) (1:1:1) (5 & 10%) & (prickly pear peel + cabbage leaves + celery leaves) (1:1:1) (5 & 10%) respectively for four weeks. At the end of the experiment, biological evaluation (BWG, FI & FER), oxidative stress parameters, CRP, lipids profile & liver enzymes were estimated. The results indicated that nicotine injection caused significant decreases in BWG, FI, FER, SOD, GPx, CAT & HDL. while significant increases were recorded in MDA, CRP, TC, TG, LDL, VLDL, AST, ALT & ALP. Injected rats groups treated with various diets revealed improvement in all previous parameters.
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